Research Use Only
Follistatin 344
A naturally occurring glycoprotein that binds and neutralizes myostatin, activin, and other TGF-beta superfamily members, studied for its role in muscle growth and tissue regeneration.
Muscle GrowthGrowth Hormone
Starting at $49
Pricing
1mg
$49
🔬
COA Available
Independent purity verification
🚚
Global Shipping
6 distribution centers
🔒
Secure Checkout
Card, crypto, Zelle, CashApp
💊
Research Grade
≥98% HPLC purity
Apr 13
Ordered
Apr 14-15
Shipped
Apr 20-24
Delivered
Route
Reconstituted for research use
Frequency
Per research protocol
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Quality
COA available. Third-party testing by Finnrick Analytical.
Compound
MW
~38 kDa
Mechanism of Action
Follistatin 344 binds directly to myostatin, activin A, and other TGF-beta ligands with high affinity, preventing them from interacting with their type II receptors (ActRIIA and ActRIIB). By neutralizing myostatin signaling through the Smad2/3 pathway, follistatin removes the primary brake on muscle protein synthesis and satellite cell proliferation, resulting in muscle hypertrophy and hyperplasia in preclinical models.
Storage & Handling
Store lyophilized at -20°C. Reconstituted: 2-8°C, use within 14 days.
Published Research
Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
McPherron AC, Lawler AM, Lee SJ. — Nature (1997)
PMID: 9139826 →
Follistatin directly antagonizes activin function and blocks myostatin signaling through a novel mechanism
Lee SJ, McPherron AC. — Proceedings of the National Academy of Sciences (2001)
Viral gene delivery of follistatin enhances muscle growth and strength in nonhuman primates
Kota J, Handy CR, Haidet AM, et al. — Science Translational Medicine (2009)
🔬
COA Verified
🚚
Global Ship
💰
Volume Pricing
FAQ
Frequently Asked Questions
What is Follistatin 344?
Follistatin 344 is a naturally occurring glycoprotein that binds and neutralizes myostatin, the primary negative regulator of muscle growth. It is the 344-amino-acid precursor isoform most commonly used in muscle biology and regenerative medicine research.
How does Follistatin inhibit myostatin?
Follistatin binds directly to myostatin with high affinity, preventing it from activating ActRIIB receptors on muscle cells. This removes the inhibitory Smad2/3 signaling that normally limits muscle protein synthesis and satellite cell proliferation.
How should Follistatin 344 be stored?
Store lyophilized follistatin at -20 degrees C for long-term storage or 2-8 degrees C for short-term use. Once reconstituted, refrigerate and use within 14 days. Follistatin is sensitive to repeated freeze-thaw cycles.