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TB-500 — Thymosin Beta-4 Research Peptide

Also known as: Thymosin Beta-4

A synthetic fragment of thymosin beta-4 studied for its role in tissue repair, cell migration, and anti-inflammatory activity in research.

Tissue RepairWound HealingAnti-inflammatory

Reconstituted for research use • Per research protocol

In Stock
Single Vial Pack of 10

TB-500

CAS #: 77591-33-4
$24 and up
Ships today · Research use only
Apr 13
Ordered
Apr 14-15
Shipped
Apr 20-24
Delivered

Compound Details

Formula C212H350N56O78S
Molecular Weight 4,963.44 g/mol
CAS Number 77591-33-4
Appearance White lyophilized powder

Mechanism of Action

TB-500 upregulates actin expression, promoting cell migration, proliferation, and differentiation at injury sites. It also reduces inflammatory cytokines and promotes blood vessel formation, supporting tissue repair in preclinical models.

Overview

TB-500 is a synthetic peptide fragment of thymosin beta-4, a naturally occurring 43-amino acid protein found in virtually all human and animal cells. Thymosin beta-4 plays a central role in cell migration, blood vessel formation, and tissue repair through its interaction with actin polymerization. In preclinical studies, TB-500 has demonstrated effects on wound healing, cardiac tissue repair, hair regrowth, and reduction of inflammation. Its primary mechanism involves promoting cell migration to injury sites and upregulating actin, a protein critical for cell structure and movement. PharmaOrder offers TB-500 as a lyophilized research peptide with full COA documentation. Often studied alongside BPC-157 in tissue repair research protocols.

Pricing

5mg lyophilized vial $24
10mg lyophilized vial $39

Volume pricing available — create an account to see tiered rates.

Purity & Testing

COA available. Third-party testing by Finnrick Analytical.

Certificates of Analysis (COA) are available in your account. Third-party testing is conducted to verify identity, purity, and potency.

Storage & Handling

Store lyophilized at -20°C or 2-8°C. Reconstituted: 2-8°C, use within 30 days.

Shipping

Ships worldwide from 6 distribution centers via USPS Ground Advantage

Available for direct research purchase

Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.

Published Research

Selected peer-reviewed studies referenced in this product overview.

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Bock-Marquette I, Saxena A, White MD, et al. — Nature (2004)
Landmark study demonstrating thymosin beta-4 promotes cardiac cell migration and survival after myocardial infarction via ILK activation.
PMID: 15565145 →
Thymosin β4 promotes dermal wound healing by stimulating migration, proliferation and survival of keratinocytes
Philp D, Goldstein AL, Kleinman HK. — Experimental Cell Research (2004)
Showed thymosin beta-4 accelerates dermal wound healing by promoting keratinocyte migration, proliferation, and survival.
Thymosin beta-4 is an endogenous iron chelator and molecular switcher of inflammation resolution
Goldstein AL, Hannappel E, Sosne G, et al. — Annals of the New York Academy of Sciences (2012)
Reviews the anti-inflammatory mechanisms of thymosin beta-4 including its role as an endogenous iron chelator and inflammation resolution mediator.

Why PharmaOrder

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COA Verified
Every batch tested by independent labs. Results available in your account.
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Global Shipping
6 distribution centers worldwide. USPS Ground Advantage with tracking.
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Volume Pricing
Tiered pricing for larger orders. Create an account to unlock lower rates.

FAQ

What is the difference between TB-500 and BPC-157?
TB-500 is derived from thymosin beta-4 and primarily promotes cell migration via actin upregulation. BPC-157 is a gastric peptide that modulates nitric oxide and growth factors. They are often studied together for complementary mechanisms.
How should TB-500 be stored?
Lyophilized TB-500 should be stored at -20°C for long-term storage or 2-8°C for short-term. Reconstituted peptide should be refrigerated at 2-8°C and used within 30 days.
Is TB-500 the same as thymosin beta-4?
TB-500 is a synthetic fragment of the full thymosin beta-4 protein. It contains the active region responsible for the primary biological effects studied in research.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.

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