TB-500 has been studied for upregulation of actin expression and its association with cell migration, proliferation, and differentiation in research models. It has also been studied for inflammatory-cytokine and angiogenesis (blood-vessel formation) pathways in preclinical and in-vitro models.
Research Use Only
Best Seller
TB-500 — Thymosin Beta-4 Research Peptide
Also known as: Thymosin Beta-4
A synthetic fragment of thymosin beta-4 studied for its role in actin regulation, cell migration, and tissue-repair pathways in research models.
Tissue RepairWound HealingAnti-inflammatory
CAS 77591-33-4 • 4,963.44 g/mol • In-vitro laboratory use only • Per research workflow
TB-500 Structure
Reference identifiers are batch-specific for coded materials and are documented on the lot COA/SDS rather than inferred or estimated.
Mechanism of Action
TB-500 Overview
TB-500 is a synthetic peptide fragment of thymosin beta-4, a naturally occurring 43-amino acid protein found in virtually all human and animal cells. Thymosin beta-4 has been studied for its role in cell migration, blood vessel formation, and tissue-repair pathways through its interaction with actin polymerization. In preclinical and in-vitro models, TB-500 has been studied for cell-migration, tissue-repair, and inflammation-resolution pathways. Its proposed mechanism involves promoting cell migration in culture and upregulating actin, a protein critical for cell structure and movement. PharmaOrder offers TB-500 as a lyophilized research peptide with full COA documentation. Often studied alongside BPC-157 in tissue-repair research workflows.
Purity & Testing
TB-500 is listed as 5mg lyophilized vial; 10mg lyophilized vial. Catalog identity: CAS 77591-33-4; formula C212H350N56O78S; molecular weight 4,963.44 g/mol. The lot COA for TB-500 is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.
- Catalog configurations: 5mg lyophilized vial, 10mg lyophilized vial
- CAS: 77591-33-4
- Formula: C212H350N56O78S
- Molecular weight: 4,963.44 g/mol
See the TB-500 COA page.
Storage & Handling
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Bock-Marquette I, Saxena A, White MD, et al. — Nature (2004)
Landmark study demonstrating thymosin beta-4 promotes cardiac cell migration and survival after myocardial infarction via ILK activation.
Thymosin β4 promotes dermal wound healing by stimulating migration, proliferation and survival of keratinocytes
Philp D, Goldstein AL, Kleinman HK. — Experimental Cell Research (2004)
Showed thymosin beta-4 accelerates dermal wound healing by promoting keratinocyte migration, proliferation, and survival.
Thymosin beta-4 is an endogenous iron chelator and molecular switcher of inflammation resolution
Goldstein AL, Hannappel E, Sosne G, et al. — Annals of the New York Academy of Sciences (2012)
Reviews the anti-inflammatory mechanisms of thymosin beta-4 including its role as an endogenous iron chelator and inflammation resolution mediator.
FAQ
What is the difference between TB-500 and BPC-157?
TB-500 is derived from thymosin beta-4 and primarily promotes cell migration via actin upregulation. BPC-157 is a gastric peptide that modulates nitric oxide and growth factors. They are often studied together for complementary mechanisms.
How should TB-500 be stored?
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Is TB-500 the same as thymosin beta-4?
TB-500 is a synthetic fragment of the full thymosin beta-4 protein. It contains the active region responsible for the primary biological effects studied in research.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.
Compare TB-500
Related Products
RUO
BPC-157
A pentadecapeptide derived from human gastric juice, studied for its effects on tissue healing and cytoprotection in research settings.
$19
View Details →
RUO
GHK-Cu
A naturally occurring copper tripeptide complex studied for its effects on tissue remodeling, collagen synthesis, and cellular longevity pathways.
$70
View Details →
Ready to order TB-500?
In stock. Ships within 24 hours, with tracking.
Order Now