Ipamorelin binds to ghrelin/GHS receptors on pituitary somatotroph cells, triggering selective growth hormone release. Unlike broader GH secretagogues, it does not stimulate cortisol or prolactin secretion, resulting in a cleaner GH response profile in research models.
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Ipamorelin — Selective Growth Hormone Secretagogue
A selective growth hormone secretagogue that mimics ghrelin, studied for its ability to release GH without affecting cortisol or prolactin levels.
Growth HormoneLongevityMuscle GrowthSleep & Recovery
CAS 170851-70-4 • 711.85 g/mol • Prepared for research use • Per research workflow
Ipamorelin Structure
Reference identifiers are batch-specific for coded materials and are documented on the lot COA/SDS rather than inferred or estimated.
Mechanism of Action
Ipamorelin Overview
Ipamorelin is a synthetic pentapeptide and selective growth hormone secretagogue that mimics the action of ghrelin. Unlike other GH-releasing peptides, ipamorelin stimulates growth hormone release from the pituitary in a highly selective manner without significantly elevating cortisol, prolactin, or ACTH levels. In preclinical and in-vitro models, ipamorelin has been studied for GH pathway activity, bone-tissue signaling, and body-composition-related metabolic pathways. Its selectivity makes it a compound of interest in research workflows focused on isolated GH pathway modulation. Often studied in combination with CJC-1295, which acts through the complementary GHRH receptor pathway for synergistic growth hormone release in research models.
Purity & Testing
Ipamorelin is listed as 2mg lyophilized vial; 5mg lyophilized vial. Catalog identity: CAS 170851-70-4; formula C38H49N9O5; molecular weight 711.85 g/mol. The lot COA for Ipamorelin is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.
- Catalog configurations: 2mg lyophilized vial, 5mg lyophilized vial
- CAS: 170851-70-4
- Formula: C38H49N9O5
- Molecular weight: 711.85 g/mol
See the Ipamorelin COA page.
Storage & Handling
Store the lyophilized powder at -20°C or 2-8°C, protected from light. Bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Shipping
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Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
Ipamorelin, the first selective growth hormone secretagogue
Raun K, Hansen BS, Johansen NL, et al. — European Journal of Endocrinology (1998)
First characterization of ipamorelin as a highly selective GH secretagogue that does not affect ACTH, cortisol, prolactin, or FSH/LH release.
Growth hormone releasing peptides: clinical and basic aspects
Ghigo E, Arvat E, Giordano R, et al. — Journal of Endocrinological Investigation (2001)
Comprehensive review comparing GH secretagogues including ipamorelin, GHRP-6, and GHRP-2 with respect to selectivity and side-effect profiles.
Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats
Andersen NB, Malmlöf K, Johansen PB, et al. — Growth Hormone & IGF Research (2001)
Demonstrated ipamorelin promotes longitudinal bone growth in hypophysectomized rats with a dose-dependent response profile.
FAQ
What makes ipamorelin different from other GH secretagogues?
Ipamorelin is highly selective for growth hormone release. Unlike GHRP-6 or GHRP-2, it does not significantly increase cortisol, prolactin, or appetite-stimulating hormones, making it ideal for isolated GH research.
Can ipamorelin be combined with CJC-1295?
Yes. Ipamorelin (ghrelin receptor) and CJC-1295 (GHRH receptor) target complementary pathways and are frequently studied together for synergistic GH release effects.
How should ipamorelin be stored?
Store the lyophilized powder at -20°C for long-term or 2-8°C for short-term storage, protected from light. Bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.
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