Research Use Only

GHK-Cu — Copper Tripeptide Complex Research Peptide

A naturally occurring copper tripeptide complex studied for its effects on tissue remodeling, collagen synthesis, and cellular longevity pathways.

Hair & SkinWound HealingCellular Longevity

Reconstituted for research use • Per research protocol

In Stock
Single Vial Pack of 10

GHK-Cu

CAS #: 49557-75-7
$70 and up
Ships today · Research use only
Apr 13
Ordered
Apr 14-15
Shipped
Apr 20-24
Delivered

Compound Details

Formula C14H24CuN6O4
Molecular Weight 403.92 g/mol
CAS Number 49557-75-7
Sequence
Gly-His-Lys:Cu(II)
Appearance Blue lyophilized powder

Mechanism of Action

GHK-Cu delivers bioavailable copper to cells and activates tissue remodeling pathways. It upregulates collagen, elastin, and glycosaminoglycan synthesis while promoting antioxidant enzyme expression (SOD, catalase). The copper moiety is essential for lysyl oxidase activity, which cross-links collagen and elastin fibers.

Overview

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper tripeptide found in human plasma, saliva, and urine. Plasma levels of GHK-Cu decline significantly with age, from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60. In research, GHK-Cu has been studied extensively for its roles in tissue remodeling, collagen and elastin synthesis, and anti-inflammatory signaling. It has demonstrated the ability to activate genes involved in tissue remodeling while suppressing genes associated with tissue degradation and inflammation. GHK-Cu is also studied for its antioxidant properties and its ability to promote decorin expression, which plays a role in extracellular matrix organization and tissue integrity.

Pricing

50mg lyophilized vial $70
100mg lyophilized vial $100

Volume pricing available — create an account to see tiered rates.

Purity & Testing

COA available. Third-party testing by Finnrick Analytical.

Certificates of Analysis (COA) are available in your account. Third-party testing is conducted to verify identity, purity, and potency.

Storage & Handling

Store lyophilized at -20°C or 2-8°C. Reconstituted: 2-8°C, use within 14 days.

Shipping

Ships worldwide from 6 distribution centers via USPS Ground Advantage

Available for direct research purchase

Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.

Published Research

Selected peer-reviewed studies referenced in this product overview.

The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging
Pickart L, Vasquez-Soltero JM, Margolina A. — Oxidative Medicine and Cellular Longevity (2012)
Reviews GHK-Cu antioxidant mechanisms, gene expression modulation, and its role in counteracting age-related tissue degradation.
GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration
Pickart L, Vasquez-Soltero JM, Margolina A. — BioMed Research International (2015)
Comprehensive analysis of GHK-Cu effects on collagen synthesis, wound healing, anti-inflammatory signaling, and DNA repair gene expression.
PMID: 26236730 →
Tripeptide-copper complex stimulates collagen and decorin synthesis and improves the structure of skin
Leyden JJ, Grove GL, Stephens TJ, et al. — Journal of the American Academy of Dermatology (2002)
Clinical study showing GHK-Cu cream improved skin thickness, collagen synthesis, and overall skin structure compared to placebo and retinoic acid.

Why PharmaOrder

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6 distribution centers worldwide. USPS Ground Advantage with tracking.
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Tiered pricing for larger orders. Create an account to unlock lower rates.

FAQ

What is GHK-Cu used for in research?
GHK-Cu is studied for its effects on tissue remodeling, collagen synthesis, and cellular longevity pathways. It has shown activity in antioxidant defense and anti-inflammatory signaling models.
How is GHK-Cu reconstituted?
GHK-Cu is supplied as a lyophilized powder and is reconstituted with sterile water or bacteriostatic water for research use. Reconstituted solution should be stored refrigerated at 2-8°C.
Does GHK-Cu require special storage?
Store lyophilized GHK-Cu at -20°C for long-term or 2-8°C for short-term storage. Protect from light and moisture. Reconstituted peptide should be used within 30 days.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.

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