Research Use Only

GHK-Cu — Copper Tripeptide Complex Research Peptide

A naturally occurring copper tripeptide complex studied for its effects on tissue remodeling, collagen synthesis, and cellular longevity pathways.

Hair & SkinWound HealingCellular Longevity

CAS 49557-75-7 • 403.92 g/mol • Prepared for research use • Per research workflow

GHK-Cu — research use only
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GHK-Cu

CAS #: 49557-75-7
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$25.9 one-time
Research use only
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Research Use Only
For laboratory and research purposes only. Not for human or veterinary use.
Certificate of Analysis
Third-party tested for identity, purity, and quantity — available in your account.

GHK-Cu Structure

Formula C14H24CuN6O4
Molecular Weight 403.92 g/mol
CAS Number 49557-75-7
Sequence
Gly-His-Lys:Cu(II)
Appearance Blue lyophilized powder

Reference identifiers are batch-specific for coded materials and are documented on the lot COA/SDS rather than inferred or estimated.

Mechanism of Action

GHK-Cu delivers bioavailable copper to cells and activates tissue remodeling pathways. It upregulates collagen, elastin, and glycosaminoglycan synthesis while promoting antioxidant enzyme expression (SOD, catalase). The copper moiety is essential for lysyl oxidase activity, which cross-links collagen and elastin fibers.

GHK-Cu Overview

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper tripeptide found in human plasma, saliva, and urine. Plasma levels of GHK-Cu decline significantly with age, from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60. In research, GHK-Cu has been studied extensively for its roles in tissue remodeling, collagen and elastin synthesis, and anti-inflammatory signaling. It has demonstrated the ability to activate genes involved in tissue remodeling while suppressing genes associated with tissue degradation and inflammation. GHK-Cu is also studied for its antioxidant properties and its ability to promote decorin expression, which plays a role in extracellular matrix organization and tissue integrity.

Purity & Testing

GHK-Cu is listed as 50mg lyophilized vial; 100mg lyophilized vial. Catalog identity: CAS 49557-75-7; formula C14H24CuN6O4; molecular weight 403.92 g/mol. The lot COA for GHK-Cu is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.

  • Catalog configurations: 50mg lyophilized vial, 100mg lyophilized vial
  • CAS: 49557-75-7
  • Formula: C14H24CuN6O4
  • Molecular weight: 403.92 g/mol

See the GHK-Cu COA page.

Storage & Handling

Store lyophilized powder at -20°C or 2-8°C, protected from light.

Shipping

Ships worldwide from 6 distribution centers via USPS Ground Advantage

Available for direct research purchase

Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.

Published Research

Selected peer-reviewed studies referenced in this product overview.

The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging
Pickart L, Vasquez-Soltero JM, Margolina A. — Oxidative Medicine and Cellular Longevity (2012)
Reviews GHK-Cu antioxidant mechanisms, gene expression modulation, and its role in counteracting age-related tissue degradation.
GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration
Pickart L, Vasquez-Soltero JM, Margolina A. — BioMed Research International (2015)
Comprehensive analysis of GHK-Cu effects on collagen synthesis, wound healing, anti-inflammatory signaling, and DNA repair gene expression.
PMID: 26236730 →
Tripeptide-copper complex stimulates collagen and decorin synthesis and improves the structure of skin
Leyden JJ, Grove GL, Stephens TJ, et al. — Journal of the American Academy of Dermatology (2002)
Examines GHK-Cu effects on collagen and decorin synthesis and extracellular matrix organization in skin research models.

FAQ

What is GHK-Cu used for in research?
GHK-Cu is studied for its effects on tissue remodeling, collagen synthesis, and cellular longevity pathways. It has shown activity in antioxidant defense and anti-inflammatory signaling models.
How is GHK-Cu prepared?
GHK-Cu is supplied as a lyophilized powder. For in-vitro preparation use an appropriate laboratory diluent. Bring the vial to room temperature before opening.
Does GHK-Cu require special storage?
Store the lyophilized powder at -20°C for long-term or 2-8°C for short-term storage, protected from light and moisture.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.

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