Epithalon — Telomerase-Activating Research Peptide
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural epithalamin extract, studied for its ability to activate telomerase and promote telomere elongation.
Reconstituted for research use • Per research protocol
Compound Details
Mechanism of Action
Epithalon activates the expression of the telomerase reverse transcriptase (hTERT) gene, which encodes the catalytic subunit of telomerase. By upregulating hTERT, epithalon enables telomerase to add TTAGGG repeats to the 3' ends of chromosomal telomeres, counteracting the progressive shortening that occurs during DNA replication. This telomere maintenance is associated with extended replicative capacity of somatic cells and is a key area of cellular longevity research.
Overview
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. It is a synthetic analog of epithalamin, a polypeptide extract of the pineal gland that was shown to have geroprotective properties in decades of Russian biogerontology research. The primary mechanism of interest is epithalon's ability to activate telomerase, the enzyme responsible for maintaining and elongating telomeres — the protective caps at the ends of chromosomes that shorten with each cell division. Telomere shortening is a hallmark of cellular aging, and research has demonstrated that epithalon can reactivate telomerase in human somatic cells that have reached replicative senescence, restoring their capacity for division. Additional studies in animal models have reported effects on melatonin secretion, circadian rhythm normalization, antioxidant enzyme activity, and lifespan extension. In a longitudinal study involving elderly human subjects, epithalamin administration was associated with reduced cardiovascular mortality over a 12-year follow-up period. PharmaOrder supplies COA-verified epithalon for research use.
Pricing
Volume pricing available — create an account to see tiered rates.
Purity & Testing
COA available. Third-party testing by Finnrick Analytical.
Certificates of Analysis (COA) are available in your account. Third-party testing is conducted to verify identity, purity, and potency.
Storage & Handling
Store lyophilized at -20°C. Reconstituted: 2-8°C, use within 21 days.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
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