Mazdutide — Dual GLP-1/Glucagon Receptor Agonist Research Peptide

Mazdutide activates two receptor pathways. In research models, GLP-1 receptor activation is studied for hypothalamic appetite-signaling and gastric-motility pathways. Glucagon receptor activation is studied for hepatic glycogenolysis, energy-expenditure signaling, and lipid-oxidation pathways via upregulation of CPT1a and other beta-oxidation enzymes in vitro. The combined receptor engagement is studied as a dual mechanism not achieved by GLP-1-only or GLP-1/GIP compounds.

Mazdutide is a dual-acting peptide that targets both GLP-1 and glucagon receptors simultaneously. It represents a distinct pharmacological approach from other incretin-based compounds: while po-s01 targets GLP-1 alone and po-s02 pairs GLP-1 with GIP, mazdutide combines GLP-1 with glucagon receptor activation. The glucagon component is what differentiates mazdutide mechanistically. In preclinical and in-vitro models, glucagon receptor activation is studied for hepatic lipid-oxidation pathways, energy-expenditure signaling, and receptor-mediated lipolysis pathways. This makes mazdutide of interest as a research tool that engages metabolic signaling from both sides — GLP-1-receptor pathways alongside glucagon-receptor pathways. Mazdutide has been characterized in preclinical and in-vitro studies for dual GLP-1 and glucagon receptor activity and its associated effects on lipid-metabolism and hepatic lipid-oxidation pathways at the receptor level. The hepatic lipid-oxidation pathway is a particular focus of study, as glucagon receptor activation is associated with fat-oxidation signaling in hepatic models. PharmaOrder offers mazdutide as a lyophilized research peptide with Certificate of Analysis documentation for in-vitro research applications.

Mazdutide is listed as 10mg lyophilized vial. Catalog identity: CAS 2382390-26-7; formula C207H317N45O65; molecular weight 4,476 g/mol. The lot COA for Mazdutide is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.

• Catalog configurations: 10mg lyophilized vial
• CAS: 2382390-26-7
• Formula: C207H317N45O65
• Molecular weight: 4,476 g/mol

See the Mazdutide COA page.

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