Mazdutide — Dual GLP-1/Glucagon Receptor Agonist Research Peptide
A dual GLP-1/glucagon receptor agonist peptide studied for its effects on metabolic regulation, energy expenditure, and hepatic fat reduction in research.
Reconstituted for research use • Per research protocol
Compound Details
Mechanism of Action
Mazdutide activates two receptor pathways. GLP-1 receptor activation in the hypothalamus suppresses appetite signaling and slows gastric emptying to prolong post-meal satiety. Glucagon receptor activation in the liver stimulates glycogenolysis, increases resting energy expenditure through thermogenesis, and promotes hepatic fat oxidation via upregulation of CPT1a and other beta-oxidation enzymes. The combined effect reduces energy intake while increasing energy expenditure — a dual mechanism not achieved by GLP-1-only or GLP-1/GIP compounds.
Overview
Mazdutide is a dual-acting peptide that targets both GLP-1 and glucagon receptors simultaneously. It represents a distinct pharmacological approach from other incretin-based compounds: while semaglutide targets GLP-1 alone and tirzepatide pairs GLP-1 with GIP, mazdutide combines GLP-1 with glucagon receptor activation. The glucagon component is what differentiates mazdutide mechanistically. Glucagon receptor activation promotes hepatic fat oxidation, increases resting energy expenditure through thermogenesis, and drives lipolysis. This means mazdutide addresses metabolic dysfunction from both sides — reducing caloric intake through GLP-1-mediated appetite suppression while simultaneously increasing the rate at which the body metabolizes stored fat. Clinical studies have demonstrated weight reduction of up to 18% of body weight over 48 weeks, along with favorable effects on lipid profiles, hepatic fat content, and glycemic markers. The hepatic fat reduction is particularly notable, as glucagon receptor activation directly promotes fat oxidation in the liver. PharmaOrder offers mazdutide as a lyophilized research peptide with Certificate of Analysis documentation for in-vitro research applications.
Pricing
Volume pricing available — create an account to see tiered rates.
Purity & Testing
COA available. Third-party testing by Finnrick Analytical.
Certificates of Analysis (COA) are available in your account. Third-party testing is conducted to verify identity, purity, and potency.
Storage & Handling
Store refrigerated at 2-8°C. Do not freeze.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
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FAQ
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