CJC-1295 binds to GHRH receptors on pituitary somatotroph cells, stimulating the synthesis and release of growth hormone. It amplifies the natural GH pulse without disrupting the hypothalamic-pituitary feedback axis.
Research Use Only
CJC-1295 — Growth Hormone-Releasing Hormone Analog
A synthetic GHRH analog studied for its ability to sustain elevated growth hormone levels in research models.
Growth HormoneLongevityMuscle Growth
CAS 863288-34-0 • 3,647.2 g/mol • Prepared for research use • Per research workflow
CJC-1295 Structure
Reference identifiers are batch-specific for coded materials and are documented on the lot COA/SDS rather than inferred or estimated.
Mechanism of Action
CJC-1295 Overview
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 29 amino acids. It was developed with modifications to increase biological half-life and stability compared to native GHRH. Available with or without Drug Affinity Complex (DAC), which extends the half-life from approximately 30 minutes to 8 days. In research, CJC-1295 has been studied for its ability to increase growth hormone secretion at the receptor level in preclinical and in-vitro models. The non-DAC version produces more physiological pulsatile GH release, while the DAC version provides sustained elevation. Often studied in combination with ghrelin mimetics like ipamorelin for synergistic effects on growth hormone release through complementary receptor pathways.
Purity & Testing
CJC-1295 is listed as 5mg lyophilized vial; 10mg lyophilized vial. Catalog identity: CAS 863288-34-0; formula C165H269N47O46; molecular weight 3,647.2 g/mol. The lot COA for CJC-1295 is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.
- Catalog configurations: 5mg lyophilized vial, 10mg lyophilized vial
- CAS: 863288-34-0
- Formula: C165H269N47O46
- Molecular weight: 3,647.2 g/mol
See the CJC-1295 COA page.
Storage & Handling
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Shipping
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Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
Teichman SL, Neale A, Lawrence B, et al. — Journal of Clinical Endocrinology & Metabolism (2006)
Study reporting that CJC-1295 with DAC produced sustained GH and IGF-1 elevations for 6-8 days following a single administration.
Modified GRF (1-29) in healthy male volunteers
Ionescu M, Frohman LA. — Journal of Clinical Endocrinology & Metabolism (2006)
Evaluated pharmacokinetics and GH-releasing effects of modified GRF(1-29) (CJC-1295 no DAC) in healthy males.
GH-releasing peptides and GH-releasing hormone in endocrine and non-endocrine conditions
Ghigo E, Arvat E, Camanni F. — Journal of Pediatric Endocrinology & Metabolism (2001)
Review of GHRH analogs and GH-releasing peptides, covering their synergistic mechanisms for GH secretion and clinical research applications.
FAQ
What is the difference between CJC-1295 with and without DAC?
CJC-1295 without DAC has a half-life of about 30 minutes and produces pulsatile GH release. With DAC, the half-life extends to approximately 8 days, producing sustained GH elevation. Most research workflows use the non-DAC version for more physiological GH patterns.
Can CJC-1295 be combined with ipamorelin?
Yes. CJC-1295 and ipamorelin target different receptors (GHRH vs ghrelin) and are frequently studied together for synergistic growth hormone release effects.
How is CJC-1295 stored?
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.
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