AOD-9604 — Anti-Obesity Drug Fragment (HGH 177-191)
A synthetic peptide fragment of human growth hormone (amino acids 177-191) studied for its role in fat metabolism and lipolysis without affecting blood sugar or growth.
Reconstituted for research use • Per research protocol
Compound Details
Mechanism of Action
AOD-9604 mimics the lipolytic region of human growth hormone by activating beta-3 adrenergic receptors on adipocytes. This triggers a signaling cascade that stimulates hormone-sensitive lipase, accelerating the release of stored fatty acids from fat cells for oxidation. Crucially, the peptide does not bind the full HGH receptor, so it does not promote cell proliferation, skeletal growth, or insulin resistance — isolating the fat metabolism pathway from other growth hormone effects.
Overview
AOD-9604 is a modified fragment of human growth hormone spanning amino acids 177-191, with an additional tyrosine residue at the N-terminus. Originally developed as an anti-obesity drug candidate, this peptide retains the lipolytic (fat-burning) activity of HGH while lacking the growth-promoting and diabetogenic effects associated with full-length growth hormone. This selective activity profile has made it a subject of significant research interest in metabolic science. Preclinical studies have demonstrated that AOD-9604 stimulates lipolysis — the breakdown of stored triglycerides into free fatty acids — and inhibits lipogenesis, the process by which the body converts non-fat food sources into body fat. Unlike full-length HGH, AOD-9604 does not compete for the growth hormone receptor, does not affect IGF-1 levels, and does not alter insulin sensitivity or blood glucose in animal models. AOD-9604 received Generally Recognized as Safe (GRAS) status from the FDA for use as a food supplement ingredient. Research continues into its potential applications in fat metabolism, cartilage repair, and osteoarthritis. PharmaOrder supplies COA-verified lyophilized AOD-9604 for research use, with independent third-party testing available through Finnrick.
Pricing
Volume pricing available — create an account to see tiered rates.
Purity & Testing
COA available. Third-party testing by Finnrick Analytical.
Certificates of Analysis (COA) are available in your account. Third-party testing is conducted to verify identity, purity, and potency.
Storage & Handling
Store lyophilized at -20°C or 2-8°C. Reconstituted: 2-8°C, use within 30 days.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
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