AOD-9604 corresponds to the lipolytic region of human growth hormone and is studied in vitro for its interaction with beta-3 adrenergic receptor signaling on adipocytes. Research models examine its association with hormone-sensitive lipase pathways involved in the mobilization of stored fatty acids. In these models the peptide does not bind the full HGH receptor, allowing researchers to study the lipid-metabolism pathway in isolation from other growth hormone signaling.
Research Use Only
AOD-9604 — Anti-Metabolic Research Drug Fragment (HGH 177-191)
A synthetic peptide fragment of human growth hormone (amino acids 177-191) studied for lipid-metabolism (lipolysis) pathways in vitro.
Weight ManagementMetabolic Research
CAS 221231-10-3 • 1,815.1 g/mol • For in-vitro research use • Per research workflow
AOD-9604 Structure
Reference identifiers are batch-specific for coded materials and are documented on the lot COA/SDS rather than inferred or estimated.
Mechanism of Action
AOD-9604 Overview
AOD-9604 is a modified fragment of human growth hormone spanning amino acids 177-191, with an additional tyrosine residue at the N-terminus. Originally developed as an anti-metabolic research drug candidate, this peptide has been studied for lipid-metabolism (lipolysis) pathways in vitro that are distinct from the growth-promoting signaling associated with full-length growth hormone. This selective activity profile has made it a subject of significant research interest in metabolic science. In preclinical and in-vitro models, AOD-9604 has been studied for its modulation of lipolysis — the breakdown of stored triglycerides into free fatty acids — and lipogenesis pathways. In these research models, AOD-9604 does not compete for the growth hormone receptor, does not affect IGF-1 levels, and does not alter insulin sensitivity or blood glucose. Research continues into AOD-9604 as a tool compound for the study of fat-metabolism, cartilage, and connective-tissue pathways. PharmaOrder supplies COA-available lyophilized AOD-9604 for research use, with independent third-party testing available through Finnrick.
Purity & Testing
AOD-9604 is listed as 5mg. Catalog identity: CAS 221231-10-3; formula C78H123N23O23S2; molecular weight 1,815.1 g/mol. The lot COA for AOD-9604 is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.
- Catalog configurations: 5mg
- CAS: 221231-10-3
- Formula: C78H123N23O23S2
- Molecular weight: 1,815.1 g/mol
See the AOD-9604 COA page.
Storage & Handling
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
Metabolic study of the lipolytic fragment (AOD9604) of human growth hormone
Heffernan MA, Thorburn AW, Fam B, et al. — Metabolic Research Research (2001)
Preclinical study examining AOD-9604 modulation of lipolysis and lipogenesis pathways in a rodent model, with IGF-1 levels and insulin sensitivity assessed as research endpoints.
Effects of an oral formulation of the hGH fragment AOD9604 on fat metabolism in Zucker diabetic fatty rats
Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. — Metabolic Research (2003)
Preclinical study characterizing AOD-9604 fat-metabolism pathway activity and metabolic markers in a rodent research model.
A double-blind, placebo-controlled study of the safety and efficacy of a novel anti-metabolic research drug (AOD9604)
Stier H, Vos E, Kenley D. — Journal of Endocrinology and Metabolism (2013)
Clinical study referenced for the pharmacological characterization and tolerability profile of AOD-9604.
FAQ
What is AOD-9604?
AOD-9604 is a synthetic peptide fragment corresponding to amino acids 177-191 of human growth hormone, with an added tyrosine at the N-terminus. It was originally developed as an anti-metabolic research drug candidate and is studied for lipid-metabolism (lipolysis) pathways in vitro.
How does AOD-9604 differ from HGH?
AOD-9604 retains only the fat metabolism region of growth hormone. It does not affect IGF-1 levels, blood sugar, or cell growth. This selective profile allows researchers to study lipolysis without the confounding variables of full-length HGH.
How should AOD-9604 be stored?
Store the lyophilized powder at -20 degrees C, protected from light, for long-term stability; 2-8 degrees C is suitable for short-term storage. Bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent. Avoid repeated freeze-thaw cycles.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.
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