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MOTS-c
A 16-amino-acid peptide encoded in mitochondrial DNA, studied for its role in metabolic homeostasis, exercise-induced stress response, and insulin sensitivity.
Metabolic ResearchMitochondrial HealthCellular Longevity
Starting at $70
Pricing
10mg lyophilized vial
$70
40mg lyophilized vial
$190
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Research Grade
≥98% HPLC purity
Apr 13
Ordered
Apr 14-15
Shipped
Apr 20-24
Delivered
Route
Reconstituted for research use
Frequency
Per research protocol
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Quality
COA available. Third-party testing by Finnrick Analytical.
Compound
Formula
C101H152N28O22S2
MW
2,174.64 g/mol
CAS
1627580-64-6
Mechanism of Action
MOTS-c activates AMPK through inhibition of the folate-methionine cycle at the level of AICAR transformylase, leading to accumulation of the endogenous AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR). Activated AMPK then phosphorylates downstream targets to increase glucose transporter (GLUT4) translocation, enhance fatty acid oxidation, and inhibit lipogenesis. During cellular stress, MOTS-c translocates from the cytoplasm to the nucleus, where it interacts with ARE-containing promoters to activate a protective gene expression program.
Storage & Handling
Store lyophilized at -20°C. Reconstituted: 2-8°C, use within 14 days.
Published Research
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C, Zeng J, Drew BG, et al. — Cell Metabolism (2015)
PMID: 25738459 →
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Reynolds JC, Lai RW, Woodhead JST, et al. — Nature Communications (2021)
PMID: 33473109 →
The mitochondrial-derived peptide MOTS-c translocates to the nucleus during metabolic stress
Kim KH, Son JM, Benayoun BA, Lee C. — Cell Metabolism (2018)
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FAQ
Frequently Asked Questions
What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA, discovered in 2015. It acts as a metabolic regulator by activating AMPK, enhancing glucose uptake and fatty acid oxidation. It is one of only a few known mitochondria-derived peptides with systemic signaling functions.
Why is MOTS-c called an exercise mimetic?
MOTS-c levels naturally increase during physical exercise, and it activates many of the same metabolic pathways (AMPK, glucose uptake, fat oxidation) that are stimulated by exercise. In animal studies, MOTS-c administration improved metabolic parameters similarly to exercise training.
How should MOTS-c be stored?
Store lyophilized MOTS-c at -20 degrees C for long-term storage or 2-8 degrees C for short-term use. Once reconstituted with bacteriostatic water, refrigerate and use within 28 days.