Research Use Only
Semax
A synthetic peptide derived from ACTH fragment 4-10, studied for cognitive enhancement, neuroprotection, and BDNF upregulation in research models.
Cognitive EnhancementNeuroprotection
Starting at $22
Pricing
5mg lyophilized vial
$22
10mg lyophilized vial
$27
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6 distribution centers
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Research Grade
≥98% HPLC purity
Apr 13
Ordered
Apr 14-15
Shipped
Apr 20-24
Delivered
Route
Reconstituted for research use
Frequency
Per research protocol
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Quality
COA available. Third-party testing by Finnrick Analytical.
Compound
Formula
C37H51N9O10S
MW
813.93 g/mol
CAS
80714-61-0
Mechanism of Action
Semax upregulates BDNF and NGF expression through melanocortin receptor activation. It enhances dopaminergic and serotonergic neurotransmission, promotes neuronal survival signaling, and modulates gene expression involved in neuroplasticity and immune regulation in brain tissue.
Storage & Handling
Store lyophilized at -20°C or 2-8°C. Reconstituted: 2-8°C, use within 30 days.
Published Research
Semax, an ACTH(4-10) analogue with nootropic properties, activates BDNF and trkB receptor expression in the rat hippocampus
Dolotov OV, Karpenko EA, Inozemtseva LS, et al. — Brain Research (2006)
Neuroprotective effects of the synthetic ACTH(4-10) analogue Semax in a model of incomplete global cerebral ischemia in rats
Bashkatova VG, Koshelev VB, Fadyukova OE, et al. — Neurochemical Research (2001)
Regulatory peptide Semax stimulates the expression of neurotrophic factor genes in rat brain
Agapova TY, Agniullin YV, Silachev DN, et al. — Doklady Biological Sciences (2007)
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FAQ
Frequently Asked Questions
What is semax derived from?
Semax is a synthetic analog of ACTH fragment 4-10 (Met-Glu-His-Phe-Pro-Gly-Pro). It retains the neurotrophic properties of ACTH without any corticotropic (hormonal) activity.
How does semax affect BDNF?
Semax has been shown to significantly upregulate BDNF and NGF expression in brain tissue. BDNF supports neuronal survival, differentiation, and synaptic plasticity, which are key targets in cognitive research.
How should semax be stored?
Store lyophilized semax at -20°C for long-term or 2-8°C for short-term storage. Reconstituted peptide should be refrigerated at 2-8°C and used within 30 days.