Melanotan II — Synthetic Alpha-MSH Analog for Melanocortin Research
A synthetic analog of alpha-melanocyte stimulating hormone (α-MSH) studied for its activation of melanocortin receptors (MC1R, MC3R, MC4R, MC5R) in pigmentation, metabolic, and behavioral research.
Reconstituted for research use • Per research protocol
Compound Details
Mechanism of Action
Melanotan II functions as a non-selective melanocortin receptor agonist. Its cyclic structure provides enhanced receptor binding affinity and metabolic stability compared to linear α-MSH. Upon binding MC1R on melanocytes, it activates adenylyl cyclase via Gs protein coupling, increasing cAMP levels and stimulating tyrosinase activity to drive melanin synthesis. At MC4R, activation modulates hypothalamic signaling pathways involved in energy balance and autonomic function. The broad receptor profile across MC1R, MC3R, MC4R, and MC5R accounts for the diverse biological effects observed in research settings.
Overview
Melanotan II (MT-II) is a cyclic heptapeptide and synthetic analog of alpha-melanocyte stimulating hormone (α-MSH), originally developed at the University of Arizona. As a non-selective melanocortin receptor agonist, MT-II activates multiple receptor subtypes — MC1R, MC3R, MC4R, and MC5R — making it one of the most widely studied peptides in melanocortin biology. Research interest in Melanotan II spans several distinct pathways. Its activation of MC1R, the primary melanocortin receptor expressed in melanocytes, has been extensively studied in the context of melanogenesis and UV-independent pigmentation. MC4R activation has been investigated for its role in sexual function and energy homeostasis, leading to the development of related compounds for clinical applications. MC3R and MC4R engagement has also been explored in appetite regulation and metabolic research, while broader melanocortin signaling is studied for potential anti-inflammatory and neuroprotective properties. Melanotan II remains one of the most referenced peptides in melanocortin receptor research, with hundreds of published studies examining its pharmacology, receptor selectivity, and downstream signaling cascades. PharmaOrder supplies high-purity lyophilized MT-II for research use only, with Certificates of Analysis available and independent third-party verification through Finnrick Analytical. For research use only. Not intended for human consumption.
Pricing
Volume pricing available — create an account to see tiered rates.
Purity & Testing
COA available. Third-party testing by Finnrick Analytical.
Certificates of Analysis (COA) are available in your account. Third-party testing is conducted to verify identity, purity, and potency.
Storage & Handling
Store lyophilized at 2-8°C protected from light. Reconstituted: 2-8°C, use within 28 days.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
Why PharmaOrder
FAQ
What is Melanotan II?
What melanocortin receptors does MT-II activate?
How should Melanotan II be stored?
How does Melanotan II differ from PT-141?
Compare Melanotan II
Related Products
Ready to order?
In stock. Ships within 24 hours.
Order Now