In research models, selank has been studied for modulation of GABA-A receptor expression, BDNF levels, and enkephalin degradation. Studies have examined its influence on serotonergic and noradrenergic signaling along anxiolytic-related pathways at the receptor level.
Research Use Only
Selank — Anxiolytic-Pathway Heptapeptide Research Compound
A synthetic analog of tuftsin studied for GABAergic / anxiolytic-pathway modulation and immunomodulatory pathways in research models.
Cognitive EnhancementAnti-inflammatoryImmune Support
CAS 129954-34-3 • 751.87 g/mol • Prepared for research use • Per research workflow
Selank Structure
Reference identifiers are batch-specific for coded materials and are documented on the lot COA/SDS rather than inferred or estimated.
Mechanism of Action
Selank Overview
Selank is a synthetic heptapeptide analog of tuftsin, an immunomodulatory peptide naturally produced by cleavage of the IgG heavy chain. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, selank was designed with enhanced stability through the addition of a Pro-Gly-Pro sequence. In preclinical and in-vitro research, selank has been studied for GABAergic / anxiolytic-pathway modulation. Research models have examined its effects on GABA-A receptor subunit expression and on serotonin and norepinephrine metabolism. Selank has also been studied for immunomodulatory pathways in research models, including regulation of IL-6 expression and stabilization of enkephalins.
Purity & Testing
Selank is listed as 5mg lyophilized vial. Catalog identity: CAS 129954-34-3; formula C33H57N11O9; molecular weight 751.87 g/mol. The lot COA for Selank is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.
- Catalog configurations: 5mg lyophilized vial
- CAS: 129954-34-3
- Formula: C33H57N11O9
- Molecular weight: 751.87 g/mol
See the Selank COA page.
Storage & Handling
Store the lyophilized powder at -20°C, protected from light. For in-vitro preparation use an appropriate laboratory diluent.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
Selank, an analogue of the tuftsin peptide, attenuates anxiety-related behavior in rats in the elevated plus-maze
Semenova TP, Kozlovskii II, Zakharova NM, Kozlovskaya MM. — Bulletin of Experimental Biology and Medicine (2009)
Studied selank for dose-dependent anxiolytic-pathway modulation in a rat elevated plus-maze model without sedation or motor impairment.
Selank increases the content of BDNF in rat hippocampus
Inozemtseva LS, Karpenko EA, Dolotov OV, et al. — Doklady Biological Sciences (2008)
Showed that selank administration significantly increased BDNF expression in the rat hippocampus, supporting its neurotrophic mechanism of action.
Immunomodulatory properties of the synthetic peptide Selank
Uchakina ON, Uchakin PN, Miasoedov NF, et al. — Bulletin of Experimental Biology and Medicine (2008)
Characterized selank immunomodulatory activity including regulation of IL-6 expression and modulation of monocyte cytokine production.
FAQ
What is the relationship between selank and tuftsin?
Selank is a synthetic analog of tuftsin (Thr-Lys-Pro-Arg) with an added Pro-Gly-Pro C-terminal sequence for enhanced stability. Tuftsin is a naturally occurring immunomodulatory peptide derived from IgG.
How does selank compare to semax?
Both are synthetic peptides used in nootropic research. Selank is studied primarily for GABAergic / anxiolytic-pathway modulation, while semax is studied primarily for neurotrophic pathways via BDNF upregulation. They are investigated for different but complementary pathways.
How should selank be stored?
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.
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