Tesamorelin binds GHRH receptors with high affinity in receptor-level models, a pathway studied for GH-secretagogue signaling and downstream IGF-1 modulation. It is studied for lipid-metabolism (lipolysis) pathways in vitro. Its high receptor potency makes it a frequently studied compound in GH-related metabolic research.
Research Use Only
Tesamorelin — Potent GHRH Analog Research Peptide
Also known as: Egrifta
A potent synthetic GHRH analog studied in preclinical and in-vitro models for GHRH receptor binding and lipid-metabolism (lipolysis) pathways.
Growth HormoneMetabolic Research
CAS 218949-48-5 • 5,135.83 g/mol • Prepared for research use • Per workflow
Tesamorelin Structure
Reference identifiers are batch-specific for coded materials and are documented on the lot COA/SDS rather than inferred or estimated.
Mechanism of Action
Tesamorelin Overview
Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analog and one of the most potent GHRH peptides studied in preclinical and in-vitro research. It is studied for GHRH receptor binding and GH-secretagogue activity in receptor-level and cell-culture models. Tesamorelin is studied for GHRH receptor signaling and lipid-metabolism (lipolysis) pathways in animal and cell-culture models. It is one of the most actively studied GHRH analogs in metabolic research. PharmaOrder offers tesamorelin as a lyophilized research peptide. COA available. Sold for research use only.
Purity & Testing
Purity and potency tested. COA available.
Tesamorelin is listed as 5mg/mL — 5mL vial (25mg total). Catalog identity: CAS 218949-48-5; formula C221H366N72O67S; molecular weight 5,135.83 g/mol. The lot COA for Tesamorelin is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.
- Catalog configurations: 5mg/mL — 5mL vial (25mg total)
- CAS: 218949-48-5
- Formula: C221H366N72O67S
- Molecular weight: 5,135.83 g/mol
See the Tesamorelin COA page.
Storage & Handling
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Shipping
Ships from US facility. Cold-pack included for temperature-sensitive products.
For research use only
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
Effects of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial
Falutz J, Allas S, Blot K, et al. — JAMA (2007)
Randomized trial examining tesamorelin's effect on visceral adipose tissue in an HIV-associated lipodystrophy model.
Tesamorelin, a human growth hormone-releasing factor analogue, for the treatment of visceral adipose tissue accumulation in HIV-infected patients
Falutz J, Potvin D, Mamputu JC, et al. — Journal of Clinical Endocrinology & Metabolism (2010)
Phase III extension study examining tesamorelin's visceral adipose tissue endpoints in an extended-duration model.
Growth hormone-releasing hormone in HIV lipodystrophy: a randomized controlled trial
Stanley TL, Chen CY, Branch KL, et al. — JAMA (2014)
Randomized trial examining tesamorelin's visceral fat, hepatic lipid, and lipid-profile endpoints in an HIV lipodystrophy model.
FAQ
What pathways is tesamorelin studied for?
Tesamorelin is studied for GHRH receptor binding, GH-secretagogue signaling, and lipid-metabolism (lipolysis) pathways in preclinical and in-vitro models. It is one of the most actively studied GHRH analogs in metabolic research.
How does tesamorelin compare to sermorelin in research?
Both are GHRH analogs studied for GHRH receptor binding and GH-secretagogue signaling in research models. Sermorelin is often used in broader GH-pathway research, while tesamorelin is frequently studied in lipid-metabolism research models.
What is the molecular target of tesamorelin in research models?
Tesamorelin is studied for high-affinity binding at the GHRH receptor and downstream IGF-1 pathway modulation in receptor-level and cell-culture models. Research framing focuses on receptor and pathway activity rather than any in-vivo outcome.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.
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