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5-Amino-1MQ
A small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) studied in metabolic research for its potential effects on cellular energy metabolism and fat cell regulation.
Weight ManagementMetabolic Research
Starting at $49
Pricing
50mg capsules x 30
$49
50mg capsules x 60
$89
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6 distribution centers
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Research Grade
≥98% HPLC purity
Apr 13
Ordered
Apr 14-15
Shipped
Apr 20-24
Delivered
Route
Oral (research use)
Frequency
Per research protocol
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Quality
COA available. Third-party testing by Finnrick Analytical.
Compound
Formula
C13H14N2O
MW
214.26 g/mol
CAS
42464-85-3
Mechanism of Action
5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide and depletes SAM and NAD+ in cells. By blocking NNMT, 5-Amino-1MQ increases intracellular NAD+ levels in adipocytes, boosting sirtuin activity and mitochondrial energy metabolism. This shift promotes fat cell shrinkage and enhances energy expenditure without affecting appetite signaling pathways.
Storage & Handling
Store at room temperature in a cool, dry place. Protect from moisture and light.
Published Research
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
Kraus D, Yang Q, Kong D, et al. — Nature (2014)
PMID: 24670636 →
5-Amino-1MQ, a NNMT inhibitor, decreases body weight and adiposity in obese mice
Neelakantan H, Vance V, Wetzel MD, et al. — Biochemical Pharmacology (2018)
PMID: 29355485 →
Small molecule NNMT inhibitor treats adiposity independent of food intake
Neelakantan H, Wang HY, Vance V, et al. — Biochemical Pharmacology (2017)
PMID: 28687459 →
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FAQ
Frequently Asked Questions
What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It is studied in metabolic research for its potential to increase NAD+ levels in fat cells and promote energy metabolism changes in adipose tissue.
What is NNMT and why is it relevant to metabolic research?
NNMT is an enzyme that is overexpressed in fat tissue and has been linked to obesity in preclinical studies. It depletes NAD+ and SAM, two molecules essential for cellular energy metabolism. Inhibiting NNMT is a novel research approach to studying metabolic regulation in adipocytes.
How should 5-Amino-1MQ capsules be stored?
Store 5-Amino-1MQ capsules in a cool, dry environment away from direct sunlight and moisture. Keep the container sealed when not in use. Follow standard laboratory storage protocols for small molecule research compounds.
How does 5-Amino-1MQ differ from other metabolic research compounds?
5-Amino-1MQ targets NNMT, a distinct metabolic pathway from compounds that affect appetite, nutrient absorption, or hormone signaling. Preclinical research suggests it may promote fat cell shrinkage by increasing cellular energy expenditure rather than reducing food intake.