5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide and depletes SAM and NAD+ in cells. By blocking NNMT, 5-Amino-1MQ increases intracellular NAD+ levels in adipocytes, boosting sirtuin activity and mitochondrial energy metabolism. This shift promotes fat cell shrinkage and enhances energy expenditure without affecting appetite signaling pathways.
Research Use Only
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5-Amino-1MQ — NNMT Inhibitor for Metabolic Research
A small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) studied in metabolic research for its potential effects on cellular energy metabolism and fat cell regulation.
Weight ManagementMetabolic Research
CAS 42464-85-3 • 214.26 g/mol • Oral (research use) • Per research workflow
5-Amino-1MQ Structure
Reference identifiers are batch-specific for coded materials and are documented on the lot COA/SDS rather than inferred or estimated.
Mechanism of Action
5-Amino-1MQ Overview
5-Amino-1MQ is a cell-permeable small molecule that selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue and linked to metabolic research and metabolic dysfunction. NNMT degrades SAM (S-adenosyl methionine) and reduces intracellular NAD+ levels, both of which play critical roles in energy homeostasis. By blocking NNMT activity, 5-Amino-1MQ may help restore NAD+ concentrations in adipocytes and promote healthier cellular energy metabolism. Preclinical research has shown that NNMT inhibition with 5-Amino-1MQ can reduce fat mass in diet-induced metabolic research models without affecting food intake. The compound appears to work by shrinking fat cells rather than reducing their number, increasing energy expenditure at the cellular level. Studies have also observed improvements in key metabolic markers, including cholesterol profiles and overall body composition in animal models. 5-Amino-1MQ has attracted attention as a novel research tool for studying metabolic pathways because it targets a mechanism distinct from traditional approaches. Unlike compounds that act on appetite or absorption, NNMT inhibition addresses energy metabolism directly within adipose tissue. PharmaOrder supplies 5-Amino-1MQ as non-public oral-format references for research applications, with independent third-party testing available through Finnrick Analytical. For research use only. Not intended for human consumption.
Purity & Testing
5-Amino-1MQ is listed as 50mg capsules x 30; 50mg capsules x 60. Catalog identity: CAS 42464-85-3; formula C13H14N2O; molecular weight 214.26 g/mol. The lot COA for 5-Amino-1MQ is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.
- Catalog configurations: 50mg capsules x 30, 50mg capsules x 60
- CAS: 42464-85-3
- Formula: C13H14N2O
- Molecular weight: 214.26 g/mol
See the 5-Amino-1MQ COA page.
Storage & Handling
Store at room temperature in a cool, dry place. Protect from moisture and light.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
Nicotinamide N-methyltransferase knockdown protects against diet-induced metabolic research
Kraus D, Yang Q, Kong D, et al. — Nature (2014)
Landmark study showing NNMT inhibition protects against diet-induced metabolic research by increasing NAD+ and SAM in adipose tissue, establishing the research rationale for 5-Amino-1MQ.
5-Amino-1MQ, a NNMT inhibitor, decreases body weight and adiposity in obese mice
Neelakantan H, Vance V, Wetzel MD, et al. — Biochemical Pharmacology (2018)
Demonstrated that 5-Amino-1MQ reduced fat mass and body weight in diet-induced obese mice without affecting food intake or lean mass.
Small molecule NNMT inhibitor treats adiposity independent of food intake
Neelakantan H, Wang HY, Vance V, et al. — Biochemical Pharmacology (2017)
Showed NNMT inhibition with 5-Amino-1MQ increases cellular energy expenditure in adipocytes through NAD+ salvage pathway restoration.
FAQ
What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It is studied in metabolic research for its potential to increase NAD+ levels in fat cells and promote energy metabolism changes in adipose tissue.
What is NNMT and why is it relevant to metabolic research?
NNMT is an enzyme that is overexpressed in fat tissue and has been linked to metabolic research in preclinical studies. It depletes NAD+ and SAM, two molecules essential for cellular energy metabolism. Inhibiting NNMT is a novel research approach to studying metabolic regulation in adipocytes.
How should 5-Amino-1MQ capsules be stored?
Store 5-Amino-1MQ capsules in a cool, dry environment away from direct sunlight and moisture. Keep the container sealed when not in use. Follow standard laboratory storage workflows for small molecule research compounds.
How does 5-Amino-1MQ differ from other metabolic research compounds?
5-Amino-1MQ targets NNMT, a distinct metabolic pathway from compounds that affect appetite, nutrient absorption, or hormone signaling. Preclinical research suggests it may promote fat cell shrinkage by increasing cellular energy expenditure rather than reducing food intake.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.
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