5-Amino-1MQ — NNMT Inhibitor for Metabolic Research
A small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) studied in metabolic research for its potential effects on cellular energy metabolism and fat cell regulation.
Oral (research use) • Per research protocol
Compound Details
Mechanism of Action
5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide and depletes SAM and NAD+ in cells. By blocking NNMT, 5-Amino-1MQ increases intracellular NAD+ levels in adipocytes, boosting sirtuin activity and mitochondrial energy metabolism. This shift promotes fat cell shrinkage and enhances energy expenditure without affecting appetite signaling pathways.
Overview
5-Amino-1MQ is a cell-permeable small molecule that selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue and linked to obesity and metabolic dysfunction. NNMT degrades SAM (S-adenosyl methionine) and reduces intracellular NAD+ levels, both of which play critical roles in energy homeostasis. By blocking NNMT activity, 5-Amino-1MQ may help restore NAD+ concentrations in adipocytes and promote healthier cellular energy metabolism. Preclinical research has shown that NNMT inhibition with 5-Amino-1MQ can reduce fat mass in diet-induced obesity models without affecting food intake. The compound appears to work by shrinking fat cells rather than reducing their number, increasing energy expenditure at the cellular level. Studies have also observed improvements in key metabolic markers, including cholesterol profiles and overall body composition in animal models. 5-Amino-1MQ has attracted attention as a novel research tool for studying metabolic pathways because it targets a mechanism distinct from traditional approaches. Unlike compounds that act on appetite or absorption, NNMT inhibition addresses energy metabolism directly within adipose tissue. PharmaOrder supplies 5-Amino-1MQ as oral capsules for research applications, with independent third-party testing available through Finnrick Analytical. For research use only. Not intended for human consumption.
Pricing
Volume pricing available — create an account to see tiered rates.
Purity & Testing
COA available. Third-party testing by Finnrick Analytical.
Certificates of Analysis (COA) are available in your account. Third-party testing is conducted to verify identity, purity, and potency.
Storage & Handling
Store at room temperature in a cool, dry place. Protect from moisture and light.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
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FAQ
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