Research Use Only

DSIP

A naturally occurring nonapeptide first isolated from cerebral venous blood during slow-wave sleep, studied for its role in sleep regulation, stress response, and neuroendocrine modulation.

Sleep & RecoveryNeuroprotection
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Pricing

5mg lyophilized vial $25
10mg lyophilized vial $40
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Research Grade
≥98% HPLC purity
Apr 13
Ordered
Apr 14-15
Shipped
Apr 20-24
Delivered
View lab results for DSIP →
Route
Reconstituted for research use
Frequency
Per research protocol
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Quality
COA available. Third-party testing by Finnrick Analytical.
Compound
Formula
C35H48N10O15
MW
848.81 g/mol
CAS
62568-57-4

Mechanism of Action

DSIP modulates sleep architecture by influencing delta wave sleep patterns through GABAergic and glutamatergic neurotransmitter systems in the hypothalamus and brainstem sleep centers. It promotes the transition into slow-wave (delta) sleep by enhancing the synchronization of thalamocortical oscillations. DSIP also affects stress hormone regulation via the hypothalamic-pituitary-adrenal (HPA) axis, reducing cortisol and ACTH release under stress conditions, which may contribute to its sleep-promoting effects by lowering physiological arousal at the neuroendocrine level.

Storage & Handling
Store lyophilized at -20°C. Reconstituted: 2-8°C, use within 21 days.

Published Research

Delta sleep-inducing peptide (DSIP): a still unresolved riddle
Graf MV, Kastin AJ. — Pharmacology Biochemistry and Behavior (1986)
Delta sleep-inducing peptide (DSIP): an update
Kovalzon VM, Strekalova TV. — Neuroscience and Behavioral Physiology (2006)
Treatment of chronic insomnia with delta sleep-inducing peptide
Schneider-Helmert D, Schoenenberger GA. — European Neurology (1983)
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FAQ

Frequently Asked Questions

What is DSIP?
DSIP (Delta Sleep Inducing Peptide) is a naturally occurring nonapeptide first discovered in 1977. It is found in the brain and peripheral tissues and is studied for its role in promoting slow-wave (delta) sleep and modulating the stress response.
How does DSIP differ from conventional sleep compounds?
Unlike benzodiazepines and Z-drugs that suppress REM sleep and alter sleep architecture, DSIP has been shown in research to promote natural delta-wave sleep patterns without REM suppression. It modulates sleep through neuroendocrine pathways rather than direct sedation.
Does DSIP affect the stress response?
Research indicates that DSIP modulates the HPA axis, reducing cortisol and ACTH levels under stress conditions. This stress-protective effect may contribute to its sleep-promoting properties by lowering physiological arousal.

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