DSIP — Delta Sleep Inducing Peptide for Sleep Research
A naturally occurring nonapeptide first isolated from cerebral venous blood during slow-wave sleep, studied for its role in sleep regulation, stress response, and neuroendocrine modulation.
Reconstituted for research use • Per research protocol
Compound Details
Mechanism of Action
DSIP modulates sleep architecture by influencing delta wave sleep patterns through GABAergic and glutamatergic neurotransmitter systems in the hypothalamus and brainstem sleep centers. It promotes the transition into slow-wave (delta) sleep by enhancing the synchronization of thalamocortical oscillations. DSIP also affects stress hormone regulation via the hypothalamic-pituitary-adrenal (HPA) axis, reducing cortisol and ACTH release under stress conditions, which may contribute to its sleep-promoting effects by lowering physiological arousal at the neuroendocrine level.
Overview
Delta Sleep Inducing Peptide (DSIP) is a naturally occurring nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated in 1977 from the cerebral venous blood of rabbits during electrically induced slow-wave sleep. Since its discovery, DSIP has been one of the most extensively studied sleep-related peptides, with research spanning neuroendocrinology, stress physiology, and circadian biology. DSIP is found in both free and bound forms in the hypothalamus, limbic system, and peripheral organs. Research has demonstrated that it modulates sleep architecture by promoting delta-wave (slow-wave) sleep without suppressing REM sleep — a distinction from most pharmacological sleep aids. Studies have also reported effects on cortisol and ACTH regulation, pain perception, and body temperature regulation. Beyond sleep, DSIP has been investigated for its stress-protective properties. Animal studies have shown that DSIP administration can attenuate the physiological stress response, reduce oxidative damage, and normalize disrupted circadian patterns. Clinical studies in humans with insomnia and chronic pain conditions have reported improvements in sleep quality and latency. PharmaOrder provides COA-verified DSIP for research applications.
Pricing
Volume pricing available — create an account to see tiered rates.
Purity & Testing
COA available. Third-party testing by Finnrick Analytical.
Certificates of Analysis (COA) are available in your account. Third-party testing is conducted to verify identity, purity, and potency.
Storage & Handling
Store lyophilized at -20°C. Reconstituted: 2-8°C, use within 21 days.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
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FAQ
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