DSIP modulates sleep architecture by influencing delta wave sleep patterns through GABAergic and glutamatergic neurotransmitter systems in the hypothalamus and brainstem sleep centers. It promotes the transition into slow-wave (delta) sleep by enhancing the synchronization of thalamocortical oscillations. DSIP also affects stress hormone regulation via the hypothalamic-pituitary-adrenal (HPA) axis, reducing cortisol and ACTH release under stress conditions, which may contribute to its sleep-promoting effects by lowering physiological arousal at the neuroendocrine level.
Research Use Only
DSIP — Delta Sleep Inducing Peptide for Sleep Research
A naturally occurring nonapeptide first isolated from cerebral venous blood during slow-wave sleep, studied for its role in sleep regulation, stress response, and neuroendocrine modulation.
Sleep & RecoveryNeuroprotection
CAS 62568-57-4 • 848.81 g/mol • Prepared for research use • Per research workflow
DSIP Structure
Reference identifiers are batch-specific for coded materials and are documented on the lot COA/SDS rather than inferred or estimated.
Mechanism of Action
DSIP Overview
Delta Sleep Inducing Peptide (DSIP) is a naturally occurring nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated in 1977 from the cerebral venous blood of rabbits during electrically induced slow-wave sleep. Since its discovery, DSIP has been one of the most extensively studied sleep-related peptides, with research spanning neuroendocrinology, stress physiology, and circadian biology. DSIP is found in both free and bound forms in the hypothalamus, limbic system, and peripheral organs. Research has studied DSIP for its association with sleep architecture and delta-wave (slow-wave) sleep patterns. Studies have also explored DSIP in relation to cortisol and ACTH regulation, nociceptive pathways, and thermoregulation in research models. Beyond sleep, DSIP has been investigated for its stress-protective properties in research models. Preclinical and animal studies have explored DSIP for attenuation of the physiological stress response, oxidative-stress pathways, and circadian regulation. DSIP continues to be studied at the receptor and neuroendocrine level across in-vitro and preclinical research models. PharmaOrder provides DSIP for research applications; COA available.
Purity & Testing
DSIP is listed as 5mg lyophilized vial; 10mg lyophilized vial. Catalog identity: CAS 62568-57-4; formula C35H48N10O15; molecular weight 848.81 g/mol. The lot COA for DSIP is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.
- Catalog configurations: 5mg lyophilized vial, 10mg lyophilized vial
- CAS: 62568-57-4
- Formula: C35H48N10O15
- Molecular weight: 848.81 g/mol
See the DSIP COA page.
Storage & Handling
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
Delta sleep-inducing peptide (DSIP): a still unresolved riddle
Graf MV, Kastin AJ. — Pharmacology Biochemistry and Behavior (1986)
Comprehensive early review of DSIP pharmacology, sleep-promoting effects, and neuroendocrine modulation across multiple species.
Delta sleep-inducing peptide (DSIP): an update
Kovalzon VM, Strekalova TV. — Neuroscience and Behavioral Physiology (2006)
Updated review of DSIP research covering sleep architecture effects, stress-protective properties, and HPA axis modulation.
Treatment of chronic insomnia with delta sleep-inducing peptide
Schneider-Helmert D, Schoenenberger GA. — European Neurology (1983)
Early research publication investigating DSIP in the context of sleep regulation and sleep-related neuroendocrine pathways.
FAQ
What is DSIP?
DSIP (Delta Sleep Inducing Peptide) is a naturally occurring nonapeptide first discovered in 1977. It is found in the brain and peripheral tissues and is studied for its role in promoting slow-wave (delta) sleep and modulating the stress response.
What pathways is DSIP studied for in sleep research?
DSIP is studied in research models for its association with delta-wave (slow-wave) sleep architecture and for modulation of neuroendocrine pathways rather than direct sedation. Research framing focuses on receptor-level and neuroendocrine mechanisms in preclinical and in-vitro models.
Does DSIP affect the stress response?
Research indicates that DSIP modulates the HPA axis, reducing cortisol and ACTH levels under stress conditions. This stress-protective effect may contribute to its sleep-promoting properties by lowering physiological arousal.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.
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