Research Use Only
Epithalon
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural epithalamin extract, studied for its ability to activate telomerase and promote telomere elongation.
Telomere BiologyCellular Protection
Starting at $27
Pricing
10mg lyophilized vial
$27
50mg lyophilized vial
$80
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Research Grade
≥98% HPLC purity
Apr 13
Ordered
Apr 14-15
Shipped
Apr 20-24
Delivered
Route
Reconstituted for research use
Frequency
Per research protocol
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Quality
COA available. Third-party testing by Finnrick Analytical.
Compound
Formula
C14H22N4O9
MW
390.35 g/mol
CAS
307297-39-8
Mechanism of Action
Epithalon activates the expression of the telomerase reverse transcriptase (hTERT) gene, which encodes the catalytic subunit of telomerase. By upregulating hTERT, epithalon enables telomerase to add TTAGGG repeats to the 3' ends of chromosomal telomeres, counteracting the progressive shortening that occurs during DNA replication. This telomere maintenance is associated with extended replicative capacity of somatic cells and is a key area of cellular longevity research.
Storage & Handling
Store lyophilized at -20°C. Reconstituted: 2-8°C, use within 21 days.
Published Research
Peptide promotes telomere elongation in human cells
Khavinson VK, Bondarev IE, Butyugov AA. — Bulletin of Experimental Biology and Medicine (2003)
Effect of epithalon on the age-related changes in the pineal gland and other neuroendocrine organs
Khavinson VK, Anisimov VN. — Advances in Gerontology (2000)
Geroprotective effect of the synthetic tetrapeptide epitalon
Anisimov VN, Khavinson VK, Popovich IG, et al. — Bulletin of Experimental Biology and Medicine (2002)
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FAQ
Frequently Asked Questions
What is Epithalon?
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed as an analog of the pineal gland extract epithalamin. It is studied primarily for its ability to activate telomerase and its effects on cellular longevity.
How does Epithalon relate to telomeres?
Epithalon activates telomerase, the enzyme that elongates telomeres. Telomeres are protective DNA sequences at chromosome ends that shorten with age. By reactivating telomerase in somatic cells, epithalon may counteract this aspect of cellular aging.
How should Epithalon be stored?
Store lyophilized epithalon at 2-8 degrees C. Once reconstituted with bacteriostatic water, refrigerate and use within 28 days. Protect from light and avoid repeated freeze-thaw cycles.