Research Use Only
KPV
A tripeptide (Lys-Pro-Val) derived from alpha-MSH studied for its potent anti-inflammatory properties through NF-κB signaling inhibition.
Anti-inflammatoryImmune SupportWound Healing
Starting at $130
Pricing
10mg lyophilized vial
$130
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COA Available
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Research Grade
≥98% HPLC purity
Apr 13
Ordered
Apr 14-15
Shipped
Apr 20-24
Delivered
Route
Reconstituted for research use
Frequency
Per research protocol
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Quality
COA available. Third-party testing by Finnrick Analytical.
Compound
Formula
C16H30N4O4
MW
342.43 g/mol
CAS
67727-97-3
Mechanism of Action
KPV enters cells and inhibits NF-κB activation by preventing nuclear translocation of inflammatory transcription factors. This reduces downstream production of pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β, attenuating the inflammatory cascade across multiple tissue types.
Storage & Handling
Store lyophilized at -20°C or 2-8°C. Reconstituted: 2-8°C, use within 30 days.
Published Research
Anti-inflammatory activities of alpha-MSH-related tripeptides KPV and alpha-MSH(11-13)
Brzoska T, Luger TA, Maaser C, et al. — Journal of Immunology (2008)
KPV-nanoparticles for the treatment of inflammatory bowel disease
Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. — Biomaterials (2013)
Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, anti-inflammatory, and protective effects
Luger TA, Brzoska T. — Annals of the New York Academy of Sciences (2007)
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FAQ
Frequently Asked Questions
What is the origin of KPV?
KPV is derived from the C-terminal tripeptide sequence (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (alpha-MSH). Despite being only three amino acids long, research suggests it retains significant anti-inflammatory activity from the parent hormone.
What inflammatory pathways has KPV been studied for?
KPV has been studied primarily for its inhibition of NF-κB signaling, which reduces production of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β. Preclinical models have examined its effects in gut inflammation, skin inflammation, and wound healing.
How should KPV be stored?
Store lyophilized KPV at -20°C for long-term or 2-8°C for short-term storage. Reconstituted peptide should be refrigerated at 2-8°C and used within 30 days. Protect from light and repeated freeze-thaw cycles.