KPV enters cells and inhibits NF-κB activation by preventing nuclear translocation of inflammatory transcription factors. This reduces downstream production of pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β, attenuating the inflammatory cascade across multiple tissue types.
Research Use Only
KPV — Anti-Inflammatory Tripeptide Research Compound
A tripeptide (Lys-Pro-Val) derived from alpha-MSH studied for its potent anti-inflammatory properties through NF-κB signaling inhibition.
Anti-inflammatoryImmune SupportWound Healing
CAS 67727-97-3 • 342.43 g/mol • Prepared for research use • Per research workflow
KPV Structure
Reference identifiers are batch-specific for coded materials and are documented on the lot COA/SDS rather than inferred or estimated.
Mechanism of Action
KPV Overview
KPV is one of the smallest bioactive peptides studied in inflammatory research. This tripeptide, consisting of the amino acid sequence Lys-Pro-Val, is derived from the C-terminal region of alpha-melanocyte-stimulating hormone (alpha-MSH), a neuropeptide with well-documented anti-inflammatory activity. Preclinical research has demonstrated that KPV inhibits NF-κB signaling, a master regulator of the inflammatory response. Studies show it reduces the production of pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β. Its compact size allows efficient cellular uptake and tissue penetration compared to larger peptide sequences. KPV has been studied extensively in models of gut inflammation, including IBD and colitis, where it has shown effects on mucosal healing and inflammatory marker reduction. Additional research has explored its potential in skin inflammation and wound healing contexts, consistent with the broader anti-inflammatory profile of alpha-MSH-derived peptides. For research use only. Not intended for human consumption.
Purity & Testing
KPV is listed as 10mg lyophilized vial. Catalog identity: CAS 67727-97-3; formula C16H30N4O4; molecular weight 342.43 g/mol. The lot COA for KPV is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.
- Catalog configurations: 10mg lyophilized vial
- CAS: 67727-97-3
- Formula: C16H30N4O4
- Molecular weight: 342.43 g/mol
See the KPV COA page.
Storage & Handling
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Shipping
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Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
Anti-inflammatory activities of alpha-MSH-related tripeptides KPV and alpha-MSH(11-13)
Brzoska T, Luger TA, Maaser C, et al. — Journal of Immunology (2008)
Demonstrated that the KPV tripeptide retains potent anti-inflammatory activity of alpha-MSH through NF-kB inhibition in multiple cell types.
KPV-nanoparticles for the treatment of inflammatory bowel disease
Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. — Biomaterials (2013)
Showed KPV-loaded nanoparticles reduced colonic inflammation and accelerated mucosal healing in a mouse model of colitis.
Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, anti-inflammatory, and protective effects
Luger TA, Brzoska T. — Annals of the New York Academy of Sciences (2007)
Reviews alpha-MSH-derived peptides including KPV, covering their anti-inflammatory signaling through melanocortin receptors and NF-kB suppression.
FAQ
What is the origin of KPV?
KPV is derived from the C-terminal tripeptide sequence (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (alpha-MSH). Despite being only three amino acids long, research suggests it retains significant anti-inflammatory activity from the parent hormone.
What inflammatory pathways has KPV been studied for?
KPV has been studied primarily for its inhibition of NF-κB signaling, which reduces production of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β. Preclinical models have examined its effects in gut inflammation, skin inflammation, and wound healing.
How should KPV be stored?
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent. Avoid repeated freeze-thaw cycles.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.
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