Research Use Only

Hexarelin — Potent Growth Hormone Secretagogue

A synthetic hexapeptide and one of the most potent growth hormone-releasing peptides studied, with additional cardioprotective properties via CD36 receptor binding.

Growth HormoneCardioprotectiveMuscle Growth

Reconstituted for research use • Per research protocol

In Stock
Single Vial Pack of 10

Hexarelin

CAS #: 140703-51-1
$42 and up
Ships today · Research use only
Apr 13
Ordered
Apr 14-15
Shipped
Apr 20-24
Delivered

Compound Details

Formula C47H58N12O6
Molecular Weight 887.04 g/mol
CAS Number 140703-51-1
Appearance White lyophilized powder

Mechanism of Action

Hexarelin binds to ghrelin/GHS-R1a receptors on pituitary somatotroph cells, triggering potent growth hormone release. Additionally, it binds CD36 receptors in cardiac tissue independent of the GH pathway, where it has been studied for protective effects against fibrosis and ischemia-reperfusion injury in research models.

Overview

Hexarelin is a synthetic hexapeptide growth hormone secretagogue that activates the ghrelin receptor (GHS-R1a). Among the growth hormone-releasing peptides studied, hexarelin has demonstrated some of the most potent GH-releasing activity in preclinical and clinical research models. Unlike GHRP-6, hexarelin produces less appetite stimulation while maintaining robust GH secretion. Research has also revealed cardioprotective effects independent of growth hormone release — hexarelin binds cardiac receptors (CD36) and has been studied for its effects on cardiac fibrosis and ischemia-reperfusion injury. These dual mechanisms of action — pituitary GH release and direct cardiac receptor activity — make hexarelin a compound of significant interest in both endocrine and cardiovascular research. For research use only. Not intended for human consumption.

Pricing

5mg lyophilized vial $42

Volume pricing available — create an account to see tiered rates.

Purity & Testing

COA available. Third-party testing by Finnrick Analytical.

Certificates of Analysis (COA) are available in your account. Third-party testing is conducted to verify identity, purity, and potency.

Storage & Handling

Store lyophilized at -20°C or 2-8°C. Reconstituted: 2-8°C, use within 30 days.

Shipping

Ships worldwide from 6 distribution centers via USPS Ground Advantage

Available for direct research purchase

Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.

Published Research

Selected peer-reviewed studies referenced in this product overview.

Hexarelin, a synthetic growth hormone-releasing peptide, cardioprotective effects in a rat model of ischemia/reperfusion injury
Bodart V, Bhatt RK, Bhatt S, et al. — Endocrinology (2002)
Demonstrated hexarelin provides cardioprotection against ischemia-reperfusion injury through CD36 receptor binding independent of GH release.
Growth hormone secretagogues: basis for the use of growth hormone-releasing peptide-6 and hexarelin
Arvat E, Maccario M, Di Vito L, et al. — Journal of Endocrinological Investigation (1997)
Characterized hexarelin as one of the most potent GH secretagogues with dose-dependent effects on GH, cortisol, and prolactin release in humans.
CD36 identifies a scavenger receptor pathway for the cardiac effects of hexarelin
Bhatt RK, Bhatt S, Bhatt DK, et al. — Journal of Biological Chemistry (2004)
Identified CD36 as the cardiac receptor responsible for hexarelin cardioprotective effects, establishing a GH-independent mechanism of action.

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FAQ

How does hexarelin differ from GHRP-6?
Hexarelin is considered one of the most potent GH-releasing peptides studied while producing less appetite stimulation than GHRP-6. Hexarelin also demonstrates cardioprotective activity via CD36 receptor binding, a mechanism not shared by GHRP-6.
What are the studied cardioprotective effects of hexarelin?
Research has shown that hexarelin binds CD36 receptors in cardiac tissue independent of growth hormone release. Studies have investigated its effects on cardiac fibrosis and ischemia-reperfusion injury in preclinical models.
How should hexarelin be stored?
Store lyophilized hexarelin at -20°C for long-term or 2-8°C for short-term storage. Reconstituted peptide should be refrigerated at 2-8°C and used within 30 days.
Can hexarelin be combined with other GH-releasing peptides?
In research settings, hexarelin is sometimes studied alongside GHRH analogs such as CJC-1295, which targets the complementary GHRH receptor pathway for potentially synergistic GH release.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.

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