LL-37 disrupts microbial membranes through electrostatic interaction with negatively charged phospholipids. It also activates FPRL1 receptors on immune cells, promoting chemotaxis and cytokine release. Additionally, LL-37 inhibits biofilm formation and stimulates angiogenesis and re-epithelialization in wound healing models.
Research Use Only
LL-37 — Human Cathelicidin Antimicrobial Peptide
A 37-amino acid antimicrobial peptide and the only human cathelicidin, studied for broad-spectrum antimicrobial activity, immune modulation, and wound healing.
Immune SupportAnti-inflammatoryWound Healing
CAS 154947-66-7 • 4,493 g/mol • Prepared for research use • Per research workflow
LL-37 Structure
Reference identifiers are batch-specific for coded materials and are documented on the lot COA/SDS rather than inferred or estimated.
Mechanism of Action
LL-37 Overview
LL-37 is a 37-amino acid peptide and the sole cathelicidin-derived antimicrobial peptide found in humans. It is produced by cleavage of the precursor protein hCAP-18 (human cationic antimicrobial protein 18) and is expressed in neutrophils, macrophages, epithelial cells, and other immune cell types. In preclinical research, LL-37 has demonstrated broad-spectrum antimicrobial activity against gram-positive and gram-negative bacteria, fungi, and enveloped viruses. Its mechanism involves direct membrane disruption of microbial cells as well as immunomodulatory signaling through formyl peptide receptor-like 1 (FPRL1) and other pattern recognition pathways. Beyond its antimicrobial properties, LL-37 has been studied for its role in wound healing, anti-biofilm activity, and modulation of innate and adaptive immune responses. Research interest has expanded into chronic infections, inflammatory conditions, and tissue repair applications. For research use only. Not intended for human consumption.
Purity & Testing
LL-37 is listed as 10mg lyophilized vial. Catalog identity: CAS 154947-66-7; formula C205H340N60O53; molecular weight 4,493 g/mol. The lot COA for LL-37 is available in your account. Finnrick Analytical performs HPLC purity analysis and mass spectrometry identity confirmation on that lot.
- Catalog configurations: 10mg lyophilized vial
- CAS: 154947-66-7
- Formula: C205H340N60O53
- Molecular weight: 4,493 g/mol
See the LL-37 COA page.
Storage & Handling
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Shipping
Ships worldwide from 6 distribution centers via USPS Ground Advantage
Available for direct research purchase
Research-use-only products are sold strictly for laboratory and research purposes. By purchasing, you acknowledge that these products are not intended for human or veterinary use, and you agree to PharmaOrder's RUO terms of service.
Published Research
Selected peer-reviewed studies referenced in this product overview.
Antimicrobial peptides: an emerging category of therapeutic agents
Hancock RE, Sahl HG. — Nature Biotechnology (2006)
Comprehensive review of antimicrobial peptides including LL-37, covering their mechanisms of membrane disruption and immunomodulation.
The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses
Vandamme D, Lanber B, Vergote I, Bhatt DK. — Journal of Innate Immunity (2012)
Reviews the diverse immunomodulatory functions of LL-37 beyond direct antimicrobial activity, including chemotaxis and cytokine modulation.
LL-37, the only human member of the cathelicidin family of antimicrobial peptides
Durr UH, Sudheendra US, Ramamoorthy A. — Biochimica et Biophysica Acta (2006)
Structural and functional characterization of LL-37 as the sole human cathelicidin with roles in innate immunity and wound healing.
FAQ
What is LL-37 and why is it significant?
LL-37 is the only cathelicidin antimicrobial peptide found in humans. It plays a key role in innate immunity with broad-spectrum activity against bacteria, fungi, and viruses, making it a significant target for antimicrobial and immunology research.
How does LL-37 differ from other antimicrobial peptides?
LL-37 is unique as the sole human cathelicidin. Unlike many antimicrobial peptides that only disrupt membranes, LL-37 also modulates immune responses, promotes wound healing, and inhibits biofilm formation, giving it a multifunctional research profile.
How should LL-37 be stored?
Store the lyophilized powder at -20°C, protected from light; bring to room temperature before opening. For in-vitro preparation use an appropriate laboratory diluent.
Is LL-37 available for direct purchase?
Yes. LL-37 is available for direct research purchase. It is sold for research use only (RUO) and is not intended for human consumption.
Editorial Review
Updated March 2026. Reviewed against product catalog, quality, and fulfillment standards. This page is educational and not instructions for human use. See our editorial standards and quality process.
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